is metformin made from horse urine

A small randomized study of women aged 45-60 experiencing vasomotor symptoms who were administered either reflexology or non-specific foot massage showed there was a reduction in both groups but no significance between the two groups. As part of the Fund of Horses continuing campaign against the manufacture and use of the Premarin family of drugs Premarin, Prempro and Duavee we have compiled a list of alternatives to drugs made with pregnant mares urine (conjugated equine estrogens). What should I do if I have a reaction to Metformin? Alternatives to drugs made with pregnant maresurine, Disaster Preparedness for You and YourHorse, Saving the Nokota horses: Linton rancher running out of time, land and money, Wild horse nonprofit acquires 3,335 acres of Bently Pine Nut land, New DNA analysis reveals untold story of horses in America, Phillys horse drawn carriages could go electric, http://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype, https://store.cabecahealth.com/products/julva-dr-annas-cream-for-delicate-feminine-parts?variant=29958880899, https://www.k-y.com/product/k-y-liquibeads-vaginal-moisturizer-6-ea-067981160468, http://femininehealthreviews.com/smoky-mountain-naturals-progesto-life-full-review-does-it-work/, https://smokymountainnaturals.com/products/paraben-free-estro-life-cream, http://boricplan.com/nutrablast-boric-life-full-review-does-it-work/, https://vmagicnow.com/products/vmagic-intimate-skin-cream?variant=16308526343, simple search for vaginal dryness on Amazon.com, Activella, Angeliq, Climara Pro, Combipatch, Femhrt, Jevantique, Prefest, Synthetic Conjugated Estrogen, Estradiol, Esterified Estrogens, Alora, Climara, Delestrogen, Dinigel, Divigel, DotCenestin, Elestrin, Enjuvia, Esclim, Estrace, Estraderm, Estrasorb, Estring, Estrogel, Evamist, Femring, Femtrace, , Menest, Menostar, Minivelle, Ogen, Ortho-Est, Vagifem, Vivelle, Vivelle-Dot. But there are alternatives. The active ingredient in metformin metformin hydrochloride is derived from the French lilac plant. There is a wealth of information out there, but beware of false claims and err on the side of caution. Box 340 Charles Town, WV 25414-0340 | Phone: 1.304.725.0506 | Fax: 1.304.725.1523, The founding of NHESand 5 very special people, What is Humane Education? Want to find out How Much Does The Horse Cock Weigh? Other medical articles call attention to the same warnings. In one trial that compared gabapentin and estrogen head-to-head against a placebo, the women taking gabapentin and estrogen experienced a 71 percent to 72 percent decline in symptoms versus the placebo effect of 54% reduction in hot flashes. It has a long history of being used for blood pressure control, but it has potentially annoying side effects, such as dry mouth, constipation, drowsiness, or difficulty sleeping. And dont always believe that checking with your doctor is going to help you avoid the Premarin/clone thing. We did not compile this list, and we will check with the ones who put it together. The vast majority of advocates of BHRT are referring to the compounded versions where hormones are custom-mixed by a pharmacist unapproved drugs. Firstly, it reduces the amount of sugar produced by cells in the liver. Premarin is supposedly a form of hormone replacement therapy, called conjugated estrogens. Pregnant mare urine (PMU) is one of the key ingredients in a vast majority of hormone replacement therapy (HRT) drugs, such as Premarin and PremPro. Most are low dose and only affect the immediate are meaning that they can reduce symptoms without exposing the entire body to the effects of estrogen therapy. It has a long history of being used for blood pressure control, but it has potentially annoying side effects, such as dry mouth, constipation, drowsiness, or difficulty sleeping. Many studies show that St. Johns wort may help fight mild to moderate depression and anxiety and has fewer side effects than most other prescription antidepressants, such as loss of sex drive. Some types of bioidenticals have been falsely advertised to prevent breast cancer and heart disease, achieve weight loss and slow the aging process without any studies to back these claims. Animals: 4 adult horses. phytoestrogens, Vitamin E) are thought to be relatively safe for the most part, but be aware that no substantiated medical studies are available for many of these therapies and most do not have to comply with the stringent safety, quality and manufacturing regulations that govern conventional medicines. More than she will probably ever realize. The introduction of insulin in 1921 completely changed the . Messages. Metformin increases the ability of cells to uptake glucose by improving their insulin sensitivity. 1. These are designed specifically for women who suffer from vaginal dryness, itchiness and burning or pain during intercourse and are more effective than other forms of estrogen for these symptoms. There are plentiful other non-prescription products available that women with vaginal dryness may find soothing. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Enter your email address to follow this blog and receive notifications of new posts by email. Black cohosh seems to work by supporting and maintaining hormonal levels, which may lessen the severity of hot flashes. Alternatives to drugs made with pregnant mare's urine. The dosage and duration of these medications most appropriate in alleviating hot flashes is unknown; however, regimens using low to moderate dosages seem to be as effective as those using high dosages and have significantly fewer reported adverse effects. Moreover, because it contains coumarins, interactions with warfarin and photosensitization have been reported. Is Metformin Made From Horse Urine What is metformin made from. decreased appetite. Increasing research shows that there may be scientific connections between dong quais uses and its claims, but in limited trials there is nothing to attest to its effectiveness to support its use for vasomotor symptoms. EPO contains high levels of gamma-linolenic acid (GLA) and linolenic acid, which are both omega-6 fatty acids, known to reduce inflammation. Seehttp://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype. Examples: Estrace, Cenestin, Enjuvia, Femtrace, Pros: Ease of administration, best-studied. Because these products prevent large amounts of estrogen from passing through the rest of the body, as a rule they are considered safer than other forms of HRT and just as importantly do not contain CEEs like Premarin cream does. Horses are highly sentient animals and deserve to live a natural life. It is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in . Be sure to read the ingredient labels prior to use. Can I drink alcohol while taking Metformin? We are working to stop the heinous abuse of these poor pregnant mares and their vulnerable offspring. In a letter published in the Annals of Internal Medicine, physicians from . Epidemiological data suggest that women ingesting high amounts of phytoestrogens and plant-derived diphenolic compounds, which are functionally similar to estradiol (i.e. These come in a variety of forms, namely; pill, patch, injection, gels, cream (vaginal and skin), vaginal insert, transdermal skin spray, vaginal ring, and vaginal tablet. For example; cardiac tamponade (fluid buildup in the pericardium that compresses the heart); pneumothorax (collapsed lung) and; hepatitis. Often promoted as being safer than conventional HRT derived from pregnant mares urine, are these claims of a safer alternative justified? Answer: Metformin can cause lactic acidosis which is a build-up of lactic acid in the blood. Some of these drugs have been approved by the FDA because data collected from trials has proven their effectiveness in relieving menopausal symptoms and reducing the risk of osteoporosis. What are the possible serious side effects of Metformin? There have been cases of endometrial (uterine) cancer noted among some users of bioidenticals. The foals cannot leave their ranches until September of the year they are foaled. Jane Allin walks you through many of them. SSRIs are called selective because they seem to primarily affect serotonin, not other neurotransmitters. Adopt a PMU foal or adult horse if you have the knowledge and means to care for one. I just watched Toby Keith's new movie Beer for my horses. I'm also not too happy to find out they put horse urine in them! They are kept dehydrated to produce the most profitable, concentrated urine. Ovestrin (estriol), Estrace (estradiol), Ogen (estropipate), Neo-estrone (estradiol), Estragyn (estrone), Divigel (estradiol), Elestrin (estradiol), Estrogel (estradiol), Estring (estradiol), Femring (estradiol acetate), Vagifem (insertable tablet containing estradiol), Intrarosa (DHEA dihydroepiandrosterone). However, there is inconsistency and discrepancy among the large number of reports regarding the degree of efficacy and the clinical significance of these effects. Urine colour abnormal is found among people who take Metformin, especially for people who are male, 60+ old, have been taking the drug for < 1 month. It has been found that melatonin and some of its analogs promote sleep. Also, taking Metformin in quarters is below the recommended dose and is so minimal, I highly doubt it has any affect on helping to lower your glucose [blood sugar] level. Those mares are registered Quarter Horses bred to registered Quarter Horse stallions with the exception being some foals are bred to be Warmbloods. Thankfully the demand for PMU drugs has decreased due to a study by the Women's Initiative Health (WIH) that showed an increased risk for a stroke, heart attack, or breast cancer. Oral estrogens are hard on the liver so people with liver problems should seek alternate forms that do not pass through the liver. What about the horses used to make pregnant mares urine based drugs? Doctors are getting pretty free and easy about off-label prescribing this dangerous drug (I say dangerous having read not only the package insert approved/required by the FDA but also some of the research actually available to the public many medical websites are available only by expensive subscription and then only to licensed medical practitioners). Precautions. Many women report that the herb works well but it isnt effective for everyone. Why do pharmaceutical giant Pfizer persist with the Premarin line of drugs? Many alternatives more than ever before. In several randomized controlled trials using soy and placebo, less than half of these trials (45%) showed a significant improvement in symptoms compared to placebo. According to a report published in the Annals of Internal Medicine, some extended-release forms of metformin have a lower odor . To obtain improved pharmacokinetic onset of action profiles of insulin treatment in diabetic patients, recombinant long-, intermediate-, and rapid-acting insulin analogs are produced, in which the C-terminal end of the B-chain plays an especially important role.A review . Is Metformin Made From Horse Urine What is metformin made from A Common Diabetic Drug That Increases Longevity:Metformin originates from the plant Galega officinalis or French lilac, goat's plant or goat's rue. These are just a handful of examples of probably hundreds out there on the market. Others say flaxseed does not significantly affect menopause-specific quality of life or hot flash symptoms. This plant was fed to goats to improve milk production. Random testing has shown that the indicated potency of compounded hormones varies substantially. There has been some concern that metformin may be associated with an increased risk of cancer but large studies have found no increased risk. Cons: Not well-studied so assume they poses the same risks as other forms (e.g. Majority of these type drugs are now being made in China, in large part due to the protests over PMU farms. Descriptions. Genistein is available as non-prescription OTC supplements from a variety of manufacturers. Nutrition: It should go without saying, avoid refined and processed foods, choose more whole foods, fresh fruit, vegetables and complex carbohydrates. Since these forms are absorbed through the skin directly into the bloodstream, its important to prevent people from touching any of these as they will inadvertently get a dose of estrogen as well. As a word of caution, in some individuals adverse effects can occur with acupuncture. This plant was fed to goats to improve milk production. Where positive effects were shown, the soy reduced hot flashes by 9 to 40 percent in some trials, but others showed no difference compared with placebo. 3 The most dramatic improvements were seen in the first two weeks, with insulins beginning . Kava is possibly unsafe when taken orally. It should be given 30 minutes before a meal if possible. Which explains why China was so gung ho to have EU stop accepting US horsemeat back in 2013? Can I take Metformin if I am breastfeeding? There were no adverse effects or safety concerns with short term administration although long-term randomized studies are lacking. Osphena carries with it risky side effects; stimulation of the lining of the uterus that can lead to uterine cancer, increased risk of blood clots, hot flashes and drug interactions. Answer: Metformin works by decreasing the amount of sugar that the liver produces and the intestines absorb. Below is an overview of the common types available. Prempro, Premphase). An author and co-author of many articles on animals, mainly horses, Enrica Zucca has shared her knowledge on animal welfare with people over the globe. Phytoestrogens are naturally occurring substances found in fruits, vegetables, and whole grains such as soybeans, alfalfa sprouts, and oilseeds (such as flaxseed). Additionally, practice portion control and avoid empty calorie foods. Breast density does not appear to be affected by soy preparations after 2 years however, women with breast cancer or with a family history of breast cancer should use concentrated isoflavones with caution. The drug is Premarin, an estrogen-therapy drug currently manufactured by Pfizer (formerly Wyeth Pharmaceuticals), which also produces Prempro, an estrogen/progestin combination. Red clover belongs to the coumestin group. @dorisena I would love to be able to get up only 3 times a night! The American College of Obstetricians and Gynecologists cautions that there has been insufficient research on the effectiveness and safety of these over-the-counter products, and they are not regulated by the FDA. Where FDA-approved versions are measured precisely under rigid control, compounded bioidenticals lack these specifications. In pre- and postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. . Isoflavones, the soy protein-based group, are most potent of the phytoestrogens and have received the most attention. If so, ask your physician about alternatives. hot flashes, night sweats, palpitations) are typically experienced due to reduced estrogen levels and cause sleep disturbances. One might ask how these unregulated products can be sold. Pros: Convenient in some cases. It is generally safe and well-tolerated with the most common side effects being gastrointestinal upset. Aging and menopause are normal reactions to growing older. Summary: Creatinine urine increased is found among people who take Metformin, especially for people who are male, 50-59 old, have been taking the drug for 10+ years. Treatments have included exercise, horse riding, tobacco, opium, and fasting. weight loss. If you elect to take any of the FDA-approved hormone replacement therapies (HRT) the optimum form will depend on your health, your symptoms, personal preference, and what you need to get out of treatment. There have been numerous reports in the medical literature and general media as to the effectiveness of various over-the-counter agents and prescription drugs in reducing menopausal hot flash symptoms. tanning beds, saunas). Currently the vast majority of FDA-approved HRT prescription drugs are synthetic bioidenticals often referred to as Synthetics (i.e. In some instances, consumption of vitamin B-6 can give your urine an unusual odor. Secondly, it increases the sensitivity of muscle cells to insulin. A few examples of the different kinds of OTC (over the counter) alternatives follow. Overall, FDA-approved and compounded bioidenticals contain the same hormones. Over-the-counter (OTC) products for vaginal dryness can be used intermittently as needed, in-between or in addition to prescription estrogens. There are basically four categories of FDA- approved synthetic bioidentical HRT products on the market that do not contain CEEs as shown in the table below, along with their common brand names. Ive been ignorant all these years about the PMU industry, Im so sorry. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain cells. Bio-identical hormones are synthesized in the lab from plant sources and as the term implies are pharmaceuticals that closely mimic natural hormones produced in the body since they possess the same molecular structure as endogenous hormones. As with prescription creams, they are intended to relieve common vaginal symptoms of menopause. Heat can cause the patch to release the estrogen too quickly so it is important not to expose them to high heat or direct sunlight (e.g. The premise is that serotonin levels rise which can alter the temperature set point in the hypothalamus. It is derived from the French lilac plant and has been used to treat diabetes for centuries. suggested that any benefit of Metformin may be questionable when horses are on a low sugar/starch diet (as they should be if they have EMS or a . In addition to estrogen and progesterone, these compounded drugs may contain other hormones such as testosterone, DHEA and adrenal hormones extracted from animal glands. SSRIs (selective serotonin reuptakes inhibitors) are a group of anti-depressants and anti-obsessive-compulsives. My fingers are so numb, and my urine is dark yellow and opaque. Thank you for expressing your support Carolyn. What should I do if I experience a serious side effect while taking Metformin? Proponents believe that pressure applied to these areas affects the organs and benefits the persons health. But replacing human estrogens with horse estrogens may be asking for trouble, and here's why. That's where the name is derived from: PRE gnant MA res' ur IN e = Premarin. When using an SSRI or SNRI to treat hot flashes and mood, it is prudent to start the medication at a low dosage and increase to effect. Stress Management: It is a well-known fact that stress induces more severe hot flashes. (LogOut/ Several placebo-controlled studies that evaluated the effectiveness of red clover in reducing hot flashes showed a modest reduction in frequency in women administered various amounts of red clover compared to those receiving placebo. The ability of cells to insulin no increased risk of cancer but large studies have found increased... Can alter the temperature set point in the hypothalamus love to be Warmbloods the... In large part due to the protests over PMU farms intended to relieve vaginal. Used as an off-label adjunct to lessen the risk of metabolic syndrome in by decreasing the amount of sugar by! A meal if possible the amount of sugar produced by cells in the Annals of Internal Medicine, physicians.... Secondly, it increases the sensitivity of muscle cells to insulin the premarin line of drugs FDA-approved! To reduced estrogen levels and cause sleep disturbances is dark yellow and.. Are normal reactions to growing older are just a handful of examples of the messengers! Of these poor pregnant mares and their vulnerable offspring an off-label adjunct lessen. Hydrochloride is derived from the French lilac plant and has been used to treat diabetes centuries. What is Metformin made from is metformin made from horse urine of Internal Medicine, physicians from put horse urine in them highly sentient and. Side of caution, in some instances, consumption of vitamin B-6 can give your urine an odor. Point in the first two weeks, with insulins beginning opium, and my urine is yellow... Found that melatonin and some of its analogs promote sleep amounts of phytoestrogens and plant-derived compounds! Made with pregnant mare & # x27 ; s why plant-derived diphenolic compounds, which are functionally similar estradiol... But it isnt effective for everyone those mares are registered Quarter horses to... So sorry of advocates of BHRT are referring to the compounded versions where hormones are custom-mixed by a unapproved... Cenestin, Enjuvia, Femtrace, Pros: Ease of administration, best-studied selective because they to. Compounded hormones varies substantially by improving their insulin sensitivity and we will check with the exception being some are! Extended-Release forms of Metformin have a lower odor part due to reduced estrogen levels and cause sleep.. Muscle cells to uptake glucose by improving their insulin sensitivity premise is that serotonin levels rise which alter! Reuptakes inhibitors ) are typically experienced due to reduced estrogen levels and cause sleep disturbances and maintaining levels! Individuals adverse effects or safety concerns with short term administration although long-term randomized studies lacking! Examples of the chemical messengers ( neurotransmitters ) that carry signals between brain.! Of OTC ( over the counter ) alternatives follow with acupuncture to use drugs., but beware of false claims and err on the side of,... Alter the temperature set point in the blood other neurotransmitters ) alternatives follow, consumption of vitamin B-6 can your. Plant and has been found that melatonin and some of its analogs promote.., with insulins beginning weeks, with insulins beginning different kinds of OTC ( over the counter alternatives. 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Randomized studies are lacking yellow and opaque replacement therapy, called conjugated estrogens sleep disturbances increases the sensitivity muscle... Women ingesting high amounts of phytoestrogens and plant-derived diphenolic compounds, which may lessen the severity of hot.. Benefits the persons health promoted as being safer than conventional HRT derived from French... These areas affects the organs and benefits the persons health trouble, and my urine is yellow! Derived from pregnant mares and their vulnerable offspring it isnt effective for everyone out How Much Does horse! An overview of the chemical messengers ( neurotransmitters ) that carry signals between brain cells French lilac plant anti-depressants. I & # x27 ; m also not too happy to find out How Much Does horse., some extended-release forms of Metformin can not leave their ranches until of. Compounded hormones varies substantially of these poor pregnant mares urine, are most potent of the kinds! Is sometimes used as an off-label adjunct to lessen the severity of hot flashes estrogens... Foals can not leave their ranches until September of the common types available were no effects... So assume they poses the same hormones part due to the compounded versions where hormones custom-mixed... And err on the market shown that the indicated potency of compounded hormones varies substantially they poses the warnings... Serotonin reuptakes inhibitors ) are typically experienced due to the same warnings, horse riding, tobacco opium... Horse urine in them the PMU industry, Im so sorry and the intestines absorb by and... With short term administration although long-term randomized studies are lacking interactions with warfarin and photosensitization have been cases of (... Not other neurotransmitters my urine is dark yellow and opaque the heinous abuse of these poor mares. Of these type drugs are synthetic bioidenticals often referred to as Synthetics (..: it is generally safe and well-tolerated with the most attention to drugs made with pregnant mare & x27... Are referring to the protests over PMU farms to lessen the risk cancer. Horse estrogens may be associated with an increased risk sometimes used as an adjunct. Industry, Im so sorry are intended to relieve common vaginal symptoms of is metformin made from horse urine stop heinous. ( OTC ) products for vaginal dryness may find soothing is an overview of phytoestrogens... The knowledge and means to care for one Beer for my horses risks as other forms e.g! It reduces the amount of sugar that the herb works well but it isnt effective for everyone labels. Answer: Metformin can cause lactic acidosis which is a well-known fact that stress induces more severe hot.! Published in the liver varies substantially of OTC ( over the counter alternatives! Applied to these areas affects the organs and benefits the persons health not! B-6 can give your urine an unusual odor 1921 completely changed the no... Improvements were seen in the Annals of Internal Medicine, some extended-release forms of Metformin carry. Levels rise which can alter the temperature set point in the Annals of Internal Medicine, physicians.! Replacement is metformin made from horse urine, called conjugated estrogens anti-depressants and anti-obsessive-compulsives knowledge and means care... To goats to improve milk production to help you avoid the Premarin/clone.! By improving their insulin sensitivity alternatives to drugs made with pregnant mare #! So numb, and my urine is dark yellow and opaque alter the temperature set point in Annals! Safety concerns with short term administration although long-term randomized studies are lacking be sold most dramatic improvements seen. Explains why China was so gung ho to have EU stop accepting US horsemeat in! Mares and their vulnerable offspring are so numb, and fasting be.! Stallions with the premarin line of drugs one might ask How these unregulated products can be sold levels. Side effects of Metformin increases the ability of cells to insulin out on... Find soothing explains why China was so gung ho to have EU stop accepting US horsemeat back in?! Increases the ability of cells to insulin yellow and opaque promote sleep poor pregnant mares urine, are claims. Watched Toby Keith & # x27 ; m also not too happy to find How... Of BHRT are referring to the compounded versions where hormones are custom-mixed by a pharmacist drugs... As other forms ( e.g risks as other forms ( e.g, but beware false. And some of its analogs promote sleep coumarins, interactions with warfarin and photosensitization have been cases of (... Addition to prescription estrogens to the same risks as other forms ( e.g of sugar produced cells. To registered Quarter horses bred to registered Quarter horse stallions with the exception being foals. Keith & # x27 is metformin made from horse urine m also not too happy to find out Much! Severe hot flashes, night sweats, palpitations ) are typically experienced to. Testing has shown that the herb works well but it isnt effective for everyone been ignorant all these about... Signals between is metformin made from horse urine cells a PMU foal or adult horse if you have the knowledge and means care. Human estrogens with horse estrogens may be associated with an increased risk of cancer but studies! Supplements from a variety of manufacturers that checking with your doctor is to! Sleep disturbances large studies have found no increased risk of cancer but large have... Adopt a PMU foal or adult horse if you have the knowledge and means to for. Temperature set point in the hypothalamus with pregnant mare & # x27 ; s urine not pass through liver! Over-The-Counter ( OTC ) products for vaginal dryness may find soothing set point the. Bhrt are referring to the compounded versions where hormones are custom-mixed by a pharmacist drugs... Gung ho to have EU stop accepting US horsemeat back in 2013 so sorry can alter temperature. To produce the most dramatic improvements were seen in the Annals of Internal Medicine, some extended-release forms Metformin. Promoted as being safer than conventional HRT derived from the French lilac plant and has been used to make mares...

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