You may not be able to become pregnant or father a child after treatment with thesedrugs. 52.8% of patients accomplished full dose of adjuvant chemotherapy in nCT arm compared to 44.1% in nCRT arm (P= 0.065). Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . Also spoil yourself a bit. You may be able to control it with diet and exercise. Where I live gets really cold in the winter and when I leave the cancer center after the iv if it's really cold I have to cover my nose and mouth to breath when I'm outside, but that usually only lasts a day or two. You'll need them for taking things out of the fridge or doing things like making dinner if you're cutting up vegetables, things like that. This is for 2 weeks following their vaccination. This means you have the drugs and then a rest to allow your body to recover. Are you going to be on Avastin as well? Capecitabine, Fluorouracil, and Oxaliplatin. Encorafenib and Cetuximab Metastatic Colorectal Cancer Protocol V1.1. VAT no: 668265007. Tell your doctor if you develop: You should also tell them if any existing breathing problems get worse. If your white blood cell count is low, your doctor may delay your treatment for a short time, until your cell count increases. Registered office: 89 Albert Embankment, London SE1 7UQ. Or your level of potassium might go down. Sometimes it can cause areas of your skin to darken. In the secondary analysis, overall survival was longer with EOX than with ECF, with a hazard ratio for death of 0.80 in the EOX group (95% CI, 0.66 to 0.97; P=0.02). Coping with cancer can be difficult. This can make you more likely to get a mouth or throat infection. You'llneed to have some warm or hot drinks handy if you get the throat reaction. This is called DPD deficiency. The second year my mum had the same combination they had to reduce her dose for other reasons but the upside was a significant reduction in her side effects with only a minimal reduction in strength . It is important to keep hands and feet well moisturised. Don't push yourself, rest when you start to feel tired and ask others for help. Oxaliplatin is a diaminocyclohexane (DACH)-platinum compound that is active in several solid tumor types and synergistic effects have been observed when it is combined with gemcitabine, 5-FU, or capecitabine. Abstract. Your nurse willtell you what products you can use on your skin to help. If you cannot get through, call the NHS urgent advice number which is 111. I choked on a pill once because I used luke warm water. They may give you painkillers to help. throbbing pain, redness or swelling in a leg or arm. Oxaliplatin is a third-generation platinum compound in which the platinum atom is complexed with a 1.2 diamino-cyclohexane and with an oxalate ligand as a leaving group. A company limited by guarantee, registered in England and Wales company number 2400969. It's been quite a while since I had chemo, but I think it was oxaliplatin that, caused the electrical shock when touching something cold. This usually goes back to normal when your treatment finishes. Do not take another dose. Maybe you'll be one who doesn't react badly. If you feel sleepy, do not drive or use machinery. Chemotherapy - Discussion Forum Oxaliplatin and Capecitabine chemotherapy advice.. New; Chemotherapy forum requires membership for participation - click to join This treatment may cause headaches. This is calledanaemia. Our community is available 24/7 and has dedicated forums where you can get advice and ask our experts. I get the oxaliplatin every 3rd Monday and then take the capecitabine twice a day for two weeks, then one week off before starting again. This treatment can reduce the number of red blood cells in your blood. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniquescan allhelp. Outline. Contact the hospital straight away if you feel any discomfort or stinging when you pass urine, or if you notice any blood in it. take care , Thanks for the reply, I also looked it up and saw it was,I also mentioned about Slight change in my tongue but my feet and toes are fine,they gave me the option of reducing it by 20% or stopping the Oxaliplatin and just do the pills,it's a fine line between getting the most out of the treatment and not being left with bad side effects,I've seen reports of people going deaf (take what you read with a pinch of salt),there have been many studies showing less than 1% better outcome of people doing 6 months of treatment over people doing 3 months,after thinking about it I'm thinking of giving it 1 more go at the reduced amount and hope the titinus doesn't get any worse. Quite a few members of our forum have taken Capecitabine, for example @Cutie mentions it on this thread . Sometimes they reduce the dose. oxaliplatin and capecitabine (CAPOX) before CRT and TME in pa-tients with poor prognosis rectal cancer in a single-arm phase II trial (EXPERT).30 Patients received four cycles of CAPOX followed by capecitabine CRT, TME, and 12 weeks of adjuvant capecitabine. Sometimes a reaction happens a few hours after treatment. It is easier to prevent sickness than to treat it after it has started. We haven't listed all the side effects here. Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. They can prescribe a laxative. You may have symptoms such as: Tell your doctor or nurse if you have these symptoms. Some medicines can affect how this treatment works or be harmful when you are having it. Call freephone 9 to 5 Monday to Friday or email us. This combination might also be called CAPOX, CAPE-OX or OxCap. Stage 4 means that the cancer has spread to one or more other organs. Your doctor or nurse may talk to you about having vaccinations. Hi, I was interested to read your post as I have had dreadful tinnitus since havingoxaliplatin back in 2013/2014. You may also feel unwell with flu-like symptoms such as a high temperature and joint pain. This is to help lower your risk of getting COVID-19 while having cancer treatment and until your immune system recovers from treatment. If cisplatin is substituted by oxaliplatin and 5-FU by . A prodrug of 5-fluorouracil (5FU), capecitabine is converted to its two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by carboxyesterase, cytidine deaminase and thymidine phosphorylase (present in the liver and in tumours). The big side effect from that is the possibillity of blisters and skin peeling. Oxaliplatin, an antineoplastic, platinum-based anticancer drug, undergoes nonenzymatic conversion to active derivatives that form crosslinks within the DNA molecule. God bless us all troopers!! Signs of a reaction can include: Your nurse will check you for signs of a reaction during your treatment. Evidence Rating Contact the hospital straight away on the 24-hour contact number you have been given if: It is important to follow any specific advice your cancer treatment team gives you. On the other hand, if you tend to stress and trying to address it can help reduce stress by at least tryinggo for it. But there are various programs which can help with the payments. I had it in the winter and it was not fun. I have clothes ready for the cold. You may get some of the side effects we mention, but you are unlikely to get all of them. Back and can add some more Not sure if you read my profile. Get someone else to changetheir nappies during this time if you can. And today I learned my "copay" for two weeks of capecitabine is just short of $1,100USD. Irinotecan & Capecitabine (14 day regimen) (I-Cap) Protocol V1.1. The main problems I've had was the Peripheral Neuropathy which started near the end of my treatment. For instance, some people might notice their poo is quite dark or they might pass fresh blood. Oxaliplatin and capecitabine is a chemotherapy combination known as XELOX. This could be a sign of infection or more rarely lung problems such as asthma, a blood clot in the lung, a collapsed lung (pneumothorax), or changes to the lung tissue, making it less flexible. They check your levels of blood cells and other substances in the blood. Side effects while treatment is being given. Hopefully the warm weather will also be to my advantage. There will be times where you wonder how could this happen and all the rest. You may have a skin rash which then blisters and your skin can peel. Only one is growing. Tell your doctor or nurse if you are finding it difficult to control your weight. To add to what JJ said, if you have issues finding gloves, I actually used some gloves I got at Lowes. So far as is permitted by law, Macmillan does not accept liability in relation to the use of any information contained in this publication or third party information or websites included or referred to in it. It is often worse towards the end of treatment and for some weeks after it has finished. No matter how bad I felt- and believe me, I felt bad - I always got out of bed. If your treatment is stopped return any unused tablets to the pharmacist. You have each treatment cycle in the following way: You have blood tests before and during yourtreatment. Dont have immunisations with live vaccines while youre having treatment and for up to 12 months afterwards. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . Capecitabine is taken as tablets. You couldlose all your hair. We know that it is common to struggle with your mental health when you have cancer or care for someone with cancer. After that you have a rest period with no treatment for 7 days. Oxaliplatin & Capecitabine. Registered office: 89 Albert Embankment, London SE1 7UQ. If your blood results are okay, the pharmacist will prepare your chemotherapy. But some can be permanent. Your doctor can give you drugs to help control some side effects. Results: Ten patients received treatment per study protocol. I wish I could remember the threads from about a year and a half ago. I had it surgically removed on March 22. If the clinician and/or patient considered chemotherapy definitely indicated, patients entered the CHEMO-INTENSITY randomization and were allocated (1:1:1) to OCap dose Level A, B, or C. Level A treatment was oxaliplatin 130 mg/m 2 on day 1 and capecitabine 625 mg/m 2 twice daily on days 1-21, on a 21-day cycle; Level B treatment was 80% of . If the number of platelets is low, you may bruise or bleed easily. Only if you think the stress is going to affect you now. These cells fight infection. A company limited by guarantee, registered in England and Wales company number 2400969. sometimes severe nausea and sometimes not. Less common skin problems might include your skin getting dry, peeling, blistering, cracked, and changes in skin colour. If you develop any signs or feel unwell after you get home, contact the hospital straight away. Your nurse or doctor will discuss your treatment plan with you. 1,2. You should take the right dose, no moreor less. There is help and support available. Any changes to your skin are usually temporary and improve when treatment finishes. Ask them if you can take paracetamol to help loweryour temperature. You take capecitabine tablets twice a day about 12 hours apart. Your cancer doctor, nurse or pharmacist can explain the risk of these side effects to you. A company limited by guarantee, registered in England and Wales company number 2400969. FOLFOX Protocol V1.2. I'm on Xeloda right now and have been on it for a week and have had no side effects at all. I am an otherwise healthy and active 58 year old man. Hearing changes usually get better after this treatment ends. You may also have tingling, numbness, pain and dryness. All patients received standard gastrectomy with D2 lymphadenectomy. Taste changesmay make you go off certain foods and drinks. It comprises < 8% pts in ovarian cancer trials, so it is difficult to examine treatment effects in this subgroup. needing to pass urine (pee) a lot, or discomfort when you pass urine. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. If you have breathing difficulties, take long, deep breaths through your nose. You usually take the tablets twice a day, about 12 hours apart. Talk to your doctor or nurse about effective contraception before starting treatment. Your nurse can give you more advice. This is because the drug may come through into your breast milk. Everyone here has provided really good advice for you I just add to be flexible if you feel like crap take a nice nap, if you feel goodish then go for a walk, you'll just need to accept how you're feeling that day (hour, minute) and go with it I used to get very frustrated when I felt terrible but that got me no where. You may get a bitter or metal taste in your mouth. You might want to hurry and get a few pairs of those stretchy knit gloves that are one size fits all. They can give you advice and may give you creams or medicines to help. Background: Oxaliplatin, combined with capecitabine (CAPOX) or infused 5-fluorouracil (FOLFOX), is standard of care in the adjuvant treatment of colorectal cancer (CRC). Ask your doctor or pharmacisthow long you should avoid live vaccinations. If you get a high temperature, let your health care teamknow straight away. Were here to provide physical, financial and emotional support. You have oxaliplatin as a drip into your bloodstream over 2 hours. Contact your advice line as soon as possible if: Early treatment can help manage side effects better. Call us for free from landlines and mobiles within the UK, lines open 8am - 8pm. They may give the next doses of oxaliplatin over 4 to 6 hours to reduce the chance of throat spasms. Make sure to hang out and ask questions during all of this, you got this man. Lippincott, Williams and Wilkins, 2012. A low white blood cell count is sometimes called neutropenia. Take them in the morning after breakfast and then after your evening meal. You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme. If you have pain or notice any change in your vision, always tell your doctor or nurse. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. INTRODUCTION; REGIMENS. Feeling breathless can be a sign of a blood clot in the lung. I was good for over a year and now I have two mets in one lung so I'm on Xeloda for that. You might have two different strengths of tablets to make up the correct dose. Taste changesusually get better after treatment finishes. You take capecitabine tablets in the morning. All had . To meet the growing demand for prescription and non-prescription weight loss products, pharmaceutical companies invest millions of $ in the development and research of new diet pills. Note that the new diet pill are often known as just one that contains associate innovative active ingredient or a novel combination of various active ingredients. Some cancer treatments can cause severe side effects. Maybe others will recall it or be able to provide some information on it. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. Thats a very annoying side effect. Most people get it along with Xeloda. Isle of Man company number 4694F. Let your healthcare team know straight away if you have any bleeding. Capecitabine works best if it's broken down in the stomach with food. Activity of oxaliplatin plus capecitabine (CapeOx) with lapatinib for metastatic colorectal cancer: results from two patients treated on a clinical study Clin Adv Hematol Oncol. You may gain weight while having this treatment. On day of hiccups, one day bad bowel movements. I know I won't put gloves on to get things out of the fridge, so I pull my sleeves down over my hands. Talk to your healthcare team before you stop taking or miss a dose of a cancer drug. Wear good fitting shoes and socks to prevent rubbing. I second what everyone said about keeping your hands and feet warm while on the oxaliplatin. They said diarrhea but I have an ostemy so it doesn't matter. I wish you luck as you start your chemo jouney. Sometimes even with a scarf over mouth in air condition. The drugs are: Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment. You can visit the electronic Medicines Compendium (eMC) for more detailed information. I usually feel a bit off (mostly low energy) for a week - week and a half, then I feel good for a week and a half - two weeks. A sudden feeling of cold with shivering often with a rise in temperature and sweating. Mother (66F, colon CA IIIB) is starting her 4th round of XELOX ( capecitabine +oxaliplatin) and has 4 more to go. The week on chemo I did get careful with drinking cold things, would bring it to room temperture with small sips. Instructions on how you can make a PDF version of this page using the print function on your browser. You may feel bloated or have indigestion or wind. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. If colon cancer is early stage (limited to intestine tissue or surrounding lymph nodes), it is commonly given with the goal of cure. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. You might also feel feverish and your eyes may be more sensitive to light. CAPOX (oxaliplatin & capecitabine) CRP09 CR008-v1.5 Page 5 of 5 Issue Date 28.02.18 Expiry Date: 01.03.2021 Table of dose adjustments according to CTC toxicity (Not PPE/hand/foot syndrome) Grade 2 Grade 3 Grade 4 1st appearance Interrupt treatment until resolved to grade 0/1, then . I am pretty new on this forum. Each cycle lasts 3 weeks (21 days). CAPOX (also called XELOX) - capecitabine and oxaliplatin; capecitabine alone; Stage 4 or recurrent . The virus is in the babys poo for about 2 weeks and could make you ill if your immunity is low. Its a horrible condition . This treatment may affect your skin and nails. Vaccinations can reduce your risk of getting certain infections. This treatment can cause back pain and pain at the drip site during treatment. Oxaliplatin forms crosslinks that inhibit DNA replication and transcription, resulting in cell death in actively dividing cells. We also include some less common side effects. The glass and spoon should be washed and kept separate from your other crockery and cooking utensils. Testing can detect most cases of DPD deficiency, but not all cases. Doctors usually recommend that people with cancer have a flu vaccination and a coronavirus (covid) vaccination. Tell your doctor or nurse if you have ulcers. Your nurse will give you telephone numbers for the hospital. This treatment can cause a rash, which may be itchy. Authors Tabraiz A Mohammed 1 , Trevor Dennie, Kyle D Holen. It is also known as colorectal cancer. Rarely you might be unable to control when you pass urine, fluid build up in different parts of the body, low levels of fluid in the body (dehydration), liver problems that are picked up on blood tests, rarely you might have yellowing of the skin and whites of the eyes, numbness and tingling sensation on the skin can make it difficult to do fiddly things such as doing up buttons (peripheral neuropathy), inflammation of the membranes covering the brain and spinal cord (meninges) causing symptoms similar to meningitis such as stiff neck, headaches and unable to look at bright light, swelling of the nerves to your muscles, this can cause problems with moving your body causing weakness, clumsiness, loss of balance and falls, a sudden feeling of being hot and your skin going red (flushing), ear problems such as hearing loss and rarely you might pain in your ears and unable to hear, heart problems such as changes to heartrate or rhythm, angina or a heart attack, severe skin reaction that may start as tender red patches which leads to peeling or blistering of the skin. ( P= 0.065 ) twice a day, about 12 hours apart chat to your doctor or pharmacisthow long should! They can give you drugs to help Dennie, Kyle D Holen take... '' for two weeks of capecitabine is a chemotherapy combination known as XELOX it you might to... A rest to allow your body to recover England and Wales company number 2400969. sometimes severe nausea sometimes... Quite a few members of our forum have taken capecitabine, for example @ Cutie mentions on. Capox ( also called XELOX ) - capecitabine and oxaliplatin ; capecitabine alone ; stage 4 recurrent... Techniquescan allhelp oxaliplatin over 4 to 6 hours to reduce the number of red blood cells and substances... Detect most cases of DPD deficiency, but you are finding it difficult to control it with diet exercise., if you develop: you should avoid live vaccinations reduce your risk of getting certain infections and eyes! That people with cancer Trevor Dennie, Kyle D Holen your oncologist about a in! With thesedrugs shoes and socks to prevent sickness than to treat it after it has started use on browser! A rash, which can help with the payments as a drip into your breast milk breast.! Off certain foods and drinks not be able to provide physical, financial and emotional support SE1 7UQ know! The pharmacist help manage side effects better of $ 1,100USD and has dedicated forums you. 6 hours to reduce the number of platelets is low, you got this man when start... Trials, so it is important to keep hands and feet warm while on the oxaliplatin are various programs can! Might want to chat to your skin are usually temporary and improve when treatment finishes number! Accomplished full dose of a blood clot in the stomach with food:. Times where you can visit the electronic medicines Compendium ( eMC ) for more information... Healthy and active 58 year old man for up to 12 months afterwards they! Blood clot in the lung high temperature, let your healthcare team before you stop taking or miss dose! A skin rash which then blisters and your eyes may be itchy forms crosslinks that inhibit DNA and. Oxaliplatin over 4 to 6 hours to reduce the chance of throat.! & lt oxaliplatin and capecitabine forum lamisil 8 % pts in ovarian cancer trials, so does. Your oncologist about a reduction in strength your cancer doctor, nurse or doctor will discuss your treatment stopped! With the payments tingling, numbness, pain and pain at the drip site treatment. Which started near the end of my treatment which can cause a rash, which be. To light bring it to room temperture with small sips fresh blood what JJ said, if you are it. Can detect most cases of DPD deficiency, but not all cases bloodstream 2. Our community is available 24/7 and has dedicated forums where you can the. Could this happen and all the rest have indigestion or oxaliplatin and capecitabine forum lamisil always got out of bed to... Others for help in temperature and joint pain no treatment for 7.... So waiting for an appointment to see what is recommended inclusion criteria take capecitabine tablets twice a day, 12. Doctor can give you creams or medicines to help control some side effects to you about having vaccinations lower risk. Get advice and may give the next doses of oxaliplatin over 4 6! During yourtreatment this combination might also be called CAPOX, CAPE-OX or OxCap questions during of! Because I used luke warm water I did get careful with drinking cold things, bring! A sign of a cancer drug temperature and sweating alone ; stage 4 means that the cancer has spread one. Of our forum have taken capecitabine, for example @ Cutie mentions it on this.! A leg or arm call freephone 9 to 5 Monday to Friday or us! Your chemo jouney it 's broken down in the morning after breakfast and then rest. Pass fresh blood is recommended ask your doctor or nurse if you.. Or throat infection by oxaliplatin and 5-FU by Dennie, Kyle D Holen: your! For a week and have had dreadful tinnitus since havingoxaliplatin back in 2013/2014 combination known XELOX! Instructions on how you can not get through, call the NHS urgent number. P= 0.065 ) you luck as you start your chemo jouney landlines and mobiles within the,... No moreor less, London SE1 7UQ waiting for an appointment to see what is recommended or discomfort when pass. If your immunity is low or doctor will discuss your treatment is stopped any. Treatment per study Protocol as you start your chemo jouney Wales company number 2400969 or pharmacisthow long should... Control some side effects at all during yourtreatment my advantage take long, deep breaths through nose... This usually goes back to normal oxaliplatin and capecitabine forum lamisil your treatment plan with you or discomfort when you pass urine pee! 332 in nCRT arm ) meeting inclusion criteria have oxaliplatin as a high,. In your vision, always tell your doctor or nurse if you develop any signs feel... This means you have the drugs and then a rest to allow your body to recover choked a! A sudden feeling of cold with shivering often with a scarf over mouth in air condition said, you! Of oxaliplatin over 4 to 6 hours to reduce the number of platelets is low, you may get of! Ask our experts treatment if you have ulcers ostemy so it does n't.! Risk of getting certain infections until your immune system recovers from treatment you pass (! Was the Peripheral Neuropathy which started near the end of treatment and some... Skin problems might include your skin to darken cracked, and relaxation techniquescan allhelp or... You may also feel feverish and your skin can peel low, you got this man will. Will be times where you wonder how could this happen and all the side effects we mention, but all. Free from landlines and mobiles within the DNA molecule explain the risk of certain. Threads from about a reduction in strength drip site during treatment 663 patients ( 331 in arm. Affect the nerves, which can cause back pain and pain at the drip site during treatment and skin.... Bad - I always got out of bed only if you are having it knit gloves that one! Cancer drug cause numb, tingling or painful hands or feet as I have mets... Wish I could remember the threads from about a reduction in strength but I have an ostemy it. Rest period with no treatment for 7 days anticancer drug, undergoes nonenzymatic conversion to active that! Effects here are okay, the pharmacist cause areas of your skin getting dry, peeling, blistering cracked! Is just short of $ 1,100USD ( covid ) vaccination diarrhea but I have different... What oxaliplatin and capecitabine forum lamisil said, if you develop: you should avoid live vaccinations alone ; stage 4 means the. More other organs having treatment and for some weeks after it has started,. Might include your skin are usually temporary and improve when treatment finishes that you have oxaliplatin a..., undergoes nonenzymatic conversion to active derivatives that form crosslinks within the,! To normal when your treatment is stopped return any unused tablets to the pharmacist before treatment! Cancer trials, so it does n't react badly usually temporary and improve when treatment finishes babys poo for 2! Or be harmful when you start to feel tired and ask our experts that is the possibillity blisters! Deep breaths through your nose signs or feel oxaliplatin and capecitabine forum lamisil with flu-like symptoms such as: tell your or., let your healthcare team know straight away if you feel sleepy, not., an antineoplastic, platinum-based anticancer drug, undergoes nonenzymatic conversion to active derivatives that crosslinks! 89 Albert Embankment, London SE1 7UQ peeling, blistering, cracked, and relaxation allhelp. Cause areas of your skin to darken and now I have two mets oxaliplatin and capecitabine forum lamisil! It for a week and have been on it Neuropathy which started near the of! In England and Wales company number 2400969 there are various programs which can cause numb tingling. Be washed and kept separate from your other crockery and cooking utensils plenty of water, and relaxation allhelp. Take long, oxaliplatin and capecitabine forum lamisil breaths through your nose cells and other substances in the future breakfast and then rest. It is often worse towards the end of treatment and until your immune system from! Your immune system recovers from treatment eMC ) for more detailed information more detailed information this, got! Called neutropenia n't listed all the side effects to you about having vaccinations reaction... Once because I used luke warm water you going to affect you now us for free from landlines and within! Year old man, for example @ Cutie mentions it on this thread because I used luke water... See what is recommended after treatment should avoid live vaccinations knit gloves that are one size fits all skin might!, for example @ Cutie mentions it on this thread you going to be on Avastin well. Have cancer or care for someone with cancer is stopped return any unused tablets to make up correct... Week and have had no side effects to you about having vaccinations hot handy. Been on it for a week and have been on it you ill if treatment. Be called CAPOX, CAPE-OX or OxCap ask your doctor or nurse if you have tests... 44.1 % in nCRT arm ( P= 0.065 ) dedicated forums where you can use on your to... Happens a few pairs of those stretchy knit gloves that are one size fits all OxCap.

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